Serum biomarkers of collagen remodeling are associated with intestinal fibrosis and differentiate stenotic from luminal Crohn’s disease patients: a pre- and post-resection longitudinal study
Collagen markers distinguished stenosing from luminal CD, and they correlated with histological fibrosis and chronic inflammation, promising for understanding ECM remodeling. This study highlights the need for extended follow-up to assess long-term stenosis-related outcomes.
Authors
- Johan M. Burisch (ORCID: https://orcid.org/0000-0002-3312-5139)
- Florian Rieder (ORCID: https://orcid.org/0000-0002-9087-1568)
- Pernille Dige Ovesen (ORCID: https://orcid.org/0000-0001-5513-2914)
- Jakob Benedict Seidelin (ORCID: https://orcid.org/0000-0003-3230-7966)
- Julie Rasmussen (ORCID: https://orcid.org/0000-0001-6014-6376)
- Marta Sorokina Alexdóttir (ORCID: https://orcid.org/0000-0002-7028-4307)
- Martin Pehrsson (ORCID: https://orcid.org/0000-0002-4787-5563)
- Peter‐Martin Krarup (ORCID: https://orcid.org/0000-0003-1319-1451)
- Joachim Høg Mortensen (ORCID: https://orcid.org/0000-0003-0326-7264)
- Viviane A. Lin (ORCID: https://orcid.org/0000-0002-9895-7219)
- Marwah Al-Sheikh (ORCID: https://orcid.org/0000-0002-8642-3076)
- Ronja Maria Birgitta Lagström (ORCID: https://orcid.org/0000-0002-6726-7573)
- E. Dahl (ORCID: https://orcid.org/0000-0002-1383-5619)
- Ismail Gögenür (ORCID: https://orcid.org/0000-0002-3753-268X)
- Mads Damsgaard Wewer (ORCID: https://orcid.org/0000-0001-9140-9706)
- Lene Riis (ORCID: https://orcid.org/0000-0003-4669-3159)
- Anja Poulsen (ORCID: https://orcid.org/0000-0002-0314-3467)
- Annedorte Ries
- Thomai Tsapanou-Katranara
Institutions
- University of Copenhagen (DK)
- Cleveland Clinic (US)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Cleveland Clinic Lerner College of Medicine (US)
- Zealand University Hospital (DK)
- Nordic Bioscience (Denmark) (DK)
- Zealand University Hospital Køge (DK)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf085
- Citations
- 2
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Bristol-Myers Squibb
- Pfizer
- Celgene
- Kenneth Rainin Foundation
- Intuitive Surgical
- Aase og Ejnar Danielsens Fond
- Novo Nordisk
- Aage og Johanne Louis-Hansens Fond
- Samsung
- Cilag