Suppressing MASH fibrotic progression by blocking succinate-GPR91 signaling in HSCs
HSC-specific GPR91 receptor deficiency effectively halted hepatic fibrosis, probably through 2 distinct signaling pathways: suppressing the succinate-GPR91-Gβγ-ERK/c-jun-Smad3 axis, which positively regulates HSC activation, and abrogating the GPR91-Gαi-cAMP-NF-κB pathway, which hinders their apoptosis. These findings confer GPR91 as a promising target for molecular interventions in blocking MASH-fibrotic progression.
Authors
- Qiang Deng (ORCID: https://orcid.org/0000-0002-3381-3417)
- Li Xie (ORCID: https://orcid.org/0000-0002-8675-7623)
- Qin Zhu (ORCID: https://orcid.org/0000-0002-9864-5434)
- Jia Ding (ORCID: https://orcid.org/0000-0002-7391-8520)
- Ning‐Ping Zhang (ORCID: https://orcid.org/0000-0003-1262-4331)
- Yuan Zhou (ORCID: https://orcid.org/0000-0003-4413-7490)
- Hui Chen (ORCID: https://orcid.org/0000-0001-6883-3752)
- Chang Liu (ORCID: https://orcid.org/0000-0002-2575-0970)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3617-2627)
- Yue Ma (ORCID: https://orcid.org/0000-0002-0492-3983)
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Xiuping Liu (ORCID: https://orcid.org/0000-0003-1935-950X)
- Yuli Wang (ORCID: https://orcid.org/0000-0002-5500-3351)
- Yong‐Yu Yang
- Ya-Jun Yan
- Wei Jiang (ORCID: https://orcid.org/0000-0003-3066-6105)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Jinshan Hospital of Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1097/hep.0000000000001405
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77