Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy
Our study found Metformin could alleviates fibrosis of HTMCs induced by TGFβ2 and decreased elevated IOP in mouse model.
Authors
- Yihan Liu (ORCID: https://orcid.org/0009-0004-4717-2966)
- Rumeng Zhao
- S Duan (ORCID: https://orcid.org/0000-0002-9353-5420)
- Mengli Liu (ORCID: https://orcid.org/0000-0001-9315-7434)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
- Gang Wang (ORCID: https://orcid.org/0000-0003-2459-5486)
- Zhongqiang Guo
- Pengtao Wu
- Jing Ren (ORCID: https://orcid.org/0000-0001-5778-4676)
Institutions
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Henan Provincial Eye Hospital (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1177/15593258251341598
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Natural Science Foundation of Henan Province
- National Natural Science Foundation of China-Henan Joint Fund