Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study
Dolutegravir resistance is an increasing concern. An analysis of the DTG RESIST study found that among 227 integrase sequences from 7 African countries (all non-B subtypes), 59 (26.0%) had at least 1 major drug resistance mutation (primarily G118R and E138A/K/T), with 49 (21.6%) predicted to have high-level resistance to dolutegravir.
Authors
- Guy Muula
- Aggrey Semeere (ORCID: https://orcid.org/0000-0003-1826-2239)
- Adolphe Mafoua
- Jacqueline Huwa (ORCID: https://orcid.org/0000-0001-8786-2487)
- Lydia Buzaalirwa
- Helen Byakwaga (ORCID: https://orcid.org/0000-0002-4799-1564)
- Jennifer Giandhari (ORCID: https://orcid.org/0000-0002-2944-4583)
- Cleophas Chimbetete (ORCID: https://orcid.org/0000-0002-3756-3523)
- Lavanya Singh (ORCID: https://orcid.org/0000-0002-1726-4454)
- Richard Lessells (ORCID: https://orcid.org/0000-0003-0926-710X)
- Albert Kla Minga (ORCID: https://orcid.org/0000-0003-2357-6902)
- Winnie R. Muyindike (ORCID: https://orcid.org/0000-0002-6694-2645)
- Carolyn Bolton‐Moore (ORCID: https://orcid.org/0000-0001-9103-7746)
- Roger D. Kouyos (ORCID: https://orcid.org/0000-0002-9220-8348)
- Charles Kasozi
- Peter Vanes Ebasone
- Tom Loosli (ORCID: https://orcid.org/0000-0003-2049-3562)
- Matthias Egger (ORCID: https://orcid.org/0000-0001-7462-5132)
- Arcel Christ Massamba Ndala
- Mamatha Sauermann
- Eugène Messou
- Nuri Han (ORCID: https://orcid.org/0000-0001-6279-5150)
- İpek Çelikağ (ORCID: https://orcid.org/0000-0002-2172-6463)
Institutions
- University of Bern (CH)
- Centre for Infectious Disease Research in Zambia (ZM)
- Mbarara University of Science and Technology (UG)
- University of Cape Town (ZA)
- University of Zurich (CH)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Masaka Hospital (UG)
- University of Alabama at Birmingham (US)
- University of Bristol (GB)
- Lighthouse Trust (MW)
- Institut National de la Transfusion Sanguine (FR)
- Public Health Department (IN)
- University Hospital of Zurich (CH)
- Centre Hospitalier et Universitaire de Brazzaville (CG)
- Infectious Diseases Institute (UG)
- Société de Développement des Forêts (CI)
- Institute of Social and Preventive Medicine (CH)
- Makerere University (UG)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/cid/ciaf204
- Citations
- 8
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 11.17
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institute of Allergy and Infectious Diseases