Impact of carboxymethyl dextran-asparaginase in NALM-6 cell apoptosis and autophagy.
The modified L-ASNase showed enhanced effectiveness in reducing the viability of NALM-6 cells and induced higher levels of apoptosis. Interestingly, the modified enzyme had a lesser effect on autophagy, which is important as excessive autophagy can lead to treatment resistance. These findings suggest that the modified L-ASNase may have the potential to be a more effective chemotherapeutic agent for ALL treatments.
Authors
- Mahshid Azizian (ORCID: https://orcid.org/0000-0003-1936-9214)
- Faezeh Gharechahi
- Mahboobeh Ashrafi (ORCID: https://orcid.org/0000-0001-5228-8446)
- Gholamhossein Tamaddon (ORCID: https://orcid.org/0000-0001-8158-6004)
- Marjan Chahardahcherik
Institutions
- Shiraz University (IR)
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22099/ijvr.2024.49166.7208
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Shiraz University