The role of CDX2, MUC5AC, and p53 in the evaluation of the progression of serrated lesions toward colorectal carcinoma
The risk of malignancy in serrated lesions seems lower than in conventional adenomas, however, sessile serrated lesions can be involved in the appearance of interval cancers because of flat and pale macroscopic aspects. Gastric-type intestinal metaplasia may be associated with the serrated pathway, but more studies are needed to clarify mechanisms associated with serrated carcinogenesis.
Authors
- Dan Cârţu (ORCID: https://orcid.org/0000-0001-9280-4900)
- Cristina Busuioc (ORCID: https://orcid.org/0000-0002-0392-8459)
- Sergiu Marian Cazacu (ORCID: https://orcid.org/0000-0001-9623-7683)
- Liliana Streba
- Sevastiţa Iordache (ORCID: https://orcid.org/0000-0002-6280-6136)
- Vlad Florin Iovănescu
- Mirela Marinela Florescu
- Carmen Daniela Neagoe (ORCID: https://orcid.org/0000-0001-7150-5987)
Institutions
- University of Medicine and Pharmacy of Craiova (RO)
Publication Details
- Journal
- Romanian Journal of Morphology and Embryology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.47162/rjme.66.1.09
- Citations
- 1
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 1.05