Addressing SARS-CoV-2 evolution: neutralization of emerging variants of concern by the AVX/COVID-12 ‘Patria’ vaccine based on HexaPro-S ancestral Wuhan spike or its updated BA.2.75.2 version
These findings underscore the adaptability of NDV-based platforms in addressing the evolving SARS-CoV-2 landscape and reaffirm the ongoing utility of the ancestral Patria vaccine. Together, they demonstrate the potential of these platforms to drive the development of next-generation vaccines tailored to emerging viral threats, contributing to global health equity.
Authors
- Bernardo Lozano-Dubernard (ORCID: https://orcid.org/0009-0009-6430-7080)
- Weina Sun (ORCID: https://orcid.org/0000-0002-2435-5047)
- Gabriela Mellado‐Sánchez (ORCID: https://orcid.org/0000-0002-8299-5958)
- Peter Palese (ORCID: https://orcid.org/0000-0002-0337-5823)
- Adolfo Garcı́a-Sastre (ORCID: https://orcid.org/0000-0002-6551-1827)
- Keyla Gómez-Castellano (ORCID: https://orcid.org/0000-0002-0903-0236)
- Héctor Elías Chagoya-Cortés (ORCID: https://orcid.org/0009-0006-2786-4724)
- Georgina Paz-De la Rosa (ORCID: https://orcid.org/0000-0002-0491-9271)
- David Sarfati-Mizrahi (ORCID: https://orcid.org/0009-0002-6558-6316)
- Oscar Rojas-Martínez
- Constantino López-Macı́as (ORCID: https://orcid.org/0000-0003-0530-492X)
- Juana Salinas-Trujano (ORCID: https://orcid.org/0000-0001-9071-0521)
- Sonia Mayra Pérez‐Tapia (ORCID: https://orcid.org/0000-0002-2818-8522)
- Gustavo Peralta-Sánchez (ORCID: https://orcid.org/0000-0003-1174-8455)
- Jesús Horacio Lara-Puente
- Juan C. Almagro (ORCID: https://orcid.org/0000-0001-9420-1310)
- Milagros Salazar (ORCID: https://orcid.org/0009-0008-6025-1377)
- Gregorio Carballo‐Uicab (ORCID: https://orcid.org/0000-0002-9458-0776)
- Jesús Torres-Flores (ORCID: https://orcid.org/0000-0002-2194-521X)
- Florian Krammer (ORCID: https://orcid.org/0000-0003-4121-776X)
- Ignacio Mena (ORCID: https://orcid.org/0000-0001-5464-7086)
- Ivette Mendoza-Salazar (ORCID: https://orcid.org/0000-0003-4766-4712)
- Edith González‐González (ORCID: https://orcid.org/0000-0003-4971-9262)
- Alejandro Torres-Flores (ORCID: https://orcid.org/0000-0003-3705-6692)
- Karina López-Olvera
Institutions
- Semmelweis University (HU)
- Mexican Social Security Institute (MX)
- Mexican Geological Survey (MX)
- Consejo Nacional de Ciencia y Tecnología (PY)
- Universidad Mexicana (MX)
- Centro Medico Nacional Siglo XXI (MX)
- Hospital de Especialidades (MX)
- Instituto Politécnico Nacional (MX)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1565934
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Institute of Nuclear Energy Research