The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma
CENPN directly binds to STAT3 and promotes STAT3 phosphorylation and nuclear translocation to regulate USP37 transcription, thus promoting the invasion and metastasis of nasopharyngeal carcinoma. The CENPN/STAT3/USP37 axis is expected to be a new target for nasopharyngeal carcinoma treatment.
Authors
- Yue-Long Qiao
- Wo-Er Jiao
- Lizhi Wu (ORCID: https://orcid.org/0000-0003-3013-1434)
- Yufei Wang (ORCID: https://orcid.org/0000-0002-5780-112X)
- Rui Yang (ORCID: https://orcid.org/0000-0001-6134-3400)
- Shan Xu
- Shiming Chen (ORCID: https://orcid.org/0000-0002-1216-004X)
- You Zou
Institutions
- University of Zurich (CH)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fonc.2025.1536574
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00