Network localization of regional homogeneity alterations in Parkinson’s disease
By integrating heterogeneous ReHo findings via FCNM, this study delineates robust PD-associated dysfunctional networks involving key sensory, motor, and attentional systems. This network-centric view offers a unifying perspective on PD pathophysiology, highlighting large-scale systems disruption and potentially reconciling previous localization inconsistencies. This approach underscores the value of network neuroscience for understanding PD mechanisms.
Authors
- Xianxian Zhang (ORCID: https://orcid.org/0000-0003-1238-1341)
- Yichen Zhu (ORCID: https://orcid.org/0000-0002-6966-8709)
- Zhenyu Dai (ORCID: https://orcid.org/0000-0002-7799-1231)
- Yuanyuan Song (ORCID: https://orcid.org/0000-0002-9183-5884)
- Pinglei Pan
- Hucheng Yang
- Siyu Gu
Institutions
- Yancheng Third People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fnagi.2025.1607691
- Citations
- 3
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Jiangsu Commission of Health
- Anhui Medical University
- Yancheng Science and Technology Bureau