Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival
Overall, these findings highlight a novel function for FAK in promoting ribosome biogenesis and suggest that nucleolar FAK represents a promising therapeutic target.
Authors
- Vu Nguyen (ORCID: https://orcid.org/0000-0002-4363-9803)
- Philip Reigan (ORCID: https://orcid.org/0000-0003-0346-1016)
- Molishree Joshi (ORCID: https://orcid.org/0000-0003-4109-5918)
- Madison M. Rose (ORCID: https://orcid.org/0000-0003-3827-3330)
- Rebecca E. Schweppe (ORCID: https://orcid.org/0000-0001-7502-0151)
- Umarani Pugazhenthi (ORCID: https://orcid.org/0009-0003-1065-4614)
- Madeline E. Sherlock (ORCID: https://orcid.org/0000-0002-6471-4243)
- Kirk C. Hansen (ORCID: https://orcid.org/0000-0001-5054-838X)
- M. Kellett
- Jeffrey Scott Kieft (ORCID: https://orcid.org/0000-0002-3718-1891)
- Monika Dzieciątkowska (ORCID: https://orcid.org/0000-0002-9947-2520)
- Vibha Sharma (ORCID: https://orcid.org/0009-0008-3142-2210)
Institutions
- University of Colorado Cancer Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fonc.2025.1252544
- Citations
- 2
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- Cancer League of Colorado
- National Institutes of Health
- Cancer Center, University of Colorado
- National Cancer Institute