Fatal Eosinophilia-Associated Thrombotic Microangiopathy and the Role of Renal Charcot-Leyden Crystals
Thrombotic microangiopathy (TMA) is a severe condition characterized by hemolytic anemia, thrombocytopenia, and renal impairment. 1 Its etiology includes reduced activity of ADAMTS13, complementopathies, Shiga toxins, and a range of systemic conditions collectively categorized as “secondary TMA.” Among these, a few reports have described eosinophilia-associated TMA (EA-TMA). S1-S8 Nonetheless, the pathological role of eosinophils in TMA remains poorly understood. We present a case of EA-TMA in a young woman, marked by unprecedented severity and a fatal outcome.
Authors
- H Hayami
- Yukihiro Yoshimura (ORCID: https://orcid.org/0000-0002-5046-7819)
- Yoshitaka Tatematsu
- Hiroko Minami
- Keinosuke Hizuka (ORCID: https://orcid.org/0000-0002-5650-7834)
- Yuko Kawamoto (ORCID: https://orcid.org/0000-0002-0975-0559)
- Shoichi Maruyama (ORCID: https://orcid.org/0000-0002-8858-632X)
- Shuhei Kurosawa (ORCID: https://orcid.org/0000-0001-6426-6770)
- Takashi Inoue (ORCID: https://orcid.org/0000-0002-0009-6511)
- Shigeharu Ueki (ORCID: https://orcid.org/0000-0002-3537-7735)
- R. Shimomura
- Yoshikazu Yamaguchi (ORCID: https://orcid.org/0000-0003-0725-0240)
- Noritoshi Kato (ORCID: https://orcid.org/0000-0003-3924-6887)
- Katsura Matsumoto (ORCID: https://orcid.org/0000-0002-5277-568X)
- Tomonori Nakazato (ORCID: https://orcid.org/0000-0003-3579-4018)
- Hiroyuki Hayashi (ORCID: https://orcid.org/0000-0002-7965-7405)
- Motoharu Hirano
- Takeshi Kambara
- Yuna So
- Takumi Idetsuka
Institutions
- Akita University (JP)
- Keio University (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- Yokohama City University Hospital (JP)
- Fujita Health University Hospital (JP)
- Yokohama Municipal Citizen's Hospital (JP)
- Nagoya University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.ekir.2025.05.015
- Citations
- 2
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Ministry of Health, Labour and Welfare
- Nara Medical University
- Japan Society for the Promotion of Science