AI-based staging, causal hypothesis and progression of subjects at risk of Alzheimer’s disease: a multicenter study
The AI tool showed high agreement with human assessment for staging, high accuracy with biomarkers for causal hypotheses of neurocognitive disorders and predicted progression to AD at 24-month with 89% sensitivity and 82% specificity.
Authors
- Giuseppa Maresca (ORCID: https://orcid.org/0000-0001-8247-3546)
- Francesca B. Pizzini (ORCID: https://orcid.org/0000-0002-6285-0989)
- Christian Salvatore (ORCID: https://orcid.org/0000-0001-9312-4675)
- Lilla Bonanno (ORCID: https://orcid.org/0000-0002-0282-405X)
- G. Sirabian
- Francesco Sardanelli (ORCID: https://orcid.org/0000-0001-6545-9427)
- Isabella Castiglioni (ORCID: https://orcid.org/0000-0001-7191-5417)
- Simona Aresta (ORCID: https://orcid.org/0000-0002-9032-6578)
- Petronilla Battista (ORCID: https://orcid.org/0000-0002-3120-1214)
- Moreno Zanardo (ORCID: https://orcid.org/0000-0001-9640-8534)
- Marco Alì (ORCID: https://orcid.org/0000-0001-8156-7743)
- Raffaello Nemni
- Valentina Fiolo (ORCID: https://orcid.org/0000-0002-9819-3546)
- Enrico Giuseppe Bertoldo (ORCID: https://orcid.org/0000-0002-8840-5859)
- Dario Capelli
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-9204-2678)
Institutions
- University of Verona (IT)
- University of Milan (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- IRCCS Policlinico San Donato (IT)
- Lega Italiana per la Lotta ai Tumori (IT)
- CE Technologies (United Kingdom) (GB)
- Centro Diagnostico Italiano (IT)
- Centro Neurolesi Bonino Pulejo (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fneur.2025.1568086
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research