Xiaoyao San ameliorates maternal inflammation-induced neurobehavioral deficits by modulating the microbiota-gut-brain axis in offspring
This study elucidates XYS as a multi-target therapeutic agent that coordinately modulates gut microbial ecosystems, amino acid homeostasis, and neurotransmitter homeostasis. The findings provide novel insights into the gut-brain axis mechanisms of TCM formulations, offering a scientific foundation for developing microbiota-based intervention strategies for neurodevelopmental disorders.
Authors
- Weijun Ding (ORCID: https://orcid.org/0000-0002-4933-7347)
- Xiuwen Xia (ORCID: https://orcid.org/0000-0003-1962-1221)
- Lu Zhang (ORCID: https://orcid.org/0000-0001-9890-1365)
- Jiushuang Zhu
- Youjun Yang (ORCID: https://orcid.org/0000-0003-0099-0764)
- Chunqiao Lin
- Lijie Shi (ORCID: https://orcid.org/0000-0001-5065-7543)
- Zhuoting Zhong
Institutions
- Sichuan Academy of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fphar.2025.1563496
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu University of Traditional Chinese Medicine
- Chengdu University