Integrating single-cell and bulk RNA profiles to uncover glutamine metabolism’s role in prognosis and immune dynamics in multiple myeloma
Multicohort-validated GMRGs (DLD/UBA2) drive MM progression and MM inhibitor responses. Clinical upregulation and functional silencing confirm dual therapeutic potential as prognostic biomarkers and drug-sensitizing targets.
Authors
- Feifei Che (ORCID: https://orcid.org/0000-0002-5183-1854)
- Fei Zhao (ORCID: https://orcid.org/0009-0008-6335-4777)
Institutions
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12885-025-14239-0
- Citations
- 1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77