Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial
Probiotic plus vitamin D could improve IBS-associated symptoms through gut microbiota modulation and gut barrier enhancement, with persistent benefits after treatment discontinuation.
Authors
- Diego Cepeda Mora (ORCID: https://orcid.org/0000-0002-6692-9301)
- Cesare Cremon (ORCID: https://orcid.org/0000-0002-7777-2936)
- Carlo Romano Settanni (ORCID: https://orcid.org/0000-0001-5339-1947)
- Giovanni Marasco (ORCID: https://orcid.org/0000-0001-7167-8773)
- Eleonora Durini
- Giovanni Barbara (ORCID: https://orcid.org/0000-0001-9745-0726)
- Antonio Gasbarrini (ORCID: https://orcid.org/0000-0002-6230-1779)
- Valentina Petito (ORCID: https://orcid.org/0000-0003-4396-1613)
- Martina Strazzeri
- Rossella Maresca (ORCID: https://orcid.org/0000-0002-1472-0039)
- Ebrahim Yazdi
- Franco Scaldaferri (ORCID: https://orcid.org/0000-0001-8334-7541)
- Lucrezia Laterza (ORCID: https://orcid.org/0000-0001-5515-1197)
- Gianluca Ianiro (ORCID: https://orcid.org/0000-0002-8318-0515)
- Giorgio Gargari (ORCID: https://orcid.org/0000-0001-9077-6328)
- Gaetano Coppola
- Lorenza Putignani (ORCID: https://orcid.org/0000-0003-0134-2830)
- Maria Raffaella Barbaro (ORCID: https://orcid.org/0000-0003-4438-554X)
- Chiara Marangelo (ORCID: https://orcid.org/0000-0002-6633-3938)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Milan (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda USL di Bologna (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- Link Campus University (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2025-05-18
- DOI
- https://doi.org/10.3390/nu17101708
- Citations
- 6
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.87
Funders
- Fondazione Roma