The Relationship Between Sex, Fatigue, and Post-Concussion Symptoms Differs Between Those With Mild Traumatic Brain Injury Versus Trauma Control and Healthy Control Participants

This study indicates that the vulnerability of females to report elevated PCS in the post-acute period after traumatic injury is specific to those who have incurred a concomitant mTBI. Further, only some subcomponents of fatigue independently explain variance in PCS reporting, with the groups showing variability in these associations. Further work is needed to understand whether it is the "biological" and/or "socio-environmental" aspect of being female that increases the risk of higher PCS endorsement after mTBI.