Antibacterial efficacy of the cassava (Manihot esculenta C.) leaf and pirdot (Saurauia vulcani K.) leaf extract combination against Staphylococcus aureus

<i>Staphylococcus aureus</i> is a common bacterium causing various infections. The irrational use of antibiotics can lead to resistance, prompting the exploration of alternative treatments, such as herbal plants like cassava and pirdot leaves. To evaluate the antibacterial effectiveness of a combination of cassava leaf and pirdot leaf extracts against <i>S. aureus</i>. Antibacterial activity was tested using the different concentration ratios of cassava and pirdot leaf extracts (80:20, 50:50, and 30:70), with chloramphenicol (30 µg) as the positive control and DMSO (10%) as the negative control. "The inhibition zones for the various concentrations were as follows: 80% cassava and 20% pirdot (14.14 ± 1.69 mm), 50% cassava and 50% pirdot (26.47 ± 2.15 mm), and 30% cassava and 70% pirdot (22.73 ± 1.57 mm). The positive control (chloramphenicol) showed an inhibition zone of 43.59 ± 1.03 mm. Statistical analysis (Kruskal-Wallis, <i>P</i> = 0.0001) indicated significant differences among all treatment groups, followed by Dunn's test for pairwise comparisons. The inhibition zones for the various concentrations were as follows: 80% cassava and 20% pirdot (14.14 ± 1.69 mm), 50% cassava and 50% pirdot (26.47 ± 2.15 mm), and 30% cassava and 70% pirdot (22.73 ± 1.57 mm). The positive control (chloramphenicol) had an inhibition zone of 43.59 ± 1.03 mm. Statistical analysis (Kruskal-Wallis, <i>P</i> = 0.0001) indicated significant differences between the treatment groups.