Two-step electrochemically driven synthesis of sunitinib
An electrochemical method for sunitinib synthesis was developed using iodide as a mediator, enabling sustainable amidation (72% yield) and condensation (95% yield) at room temperature. This study highlights iodide's crucial role in the reaction mechanism and the potential of graphite electrodes as eco-friendly alternatives to conventional synthetic methods.
Authors
- Ade Danova (ORCID: https://orcid.org/0000-0003-4716-1170)
- Anita Alni (ORCID: https://orcid.org/0000-0002-2849-1919)
- Robby Gus Mahardika (ORCID: https://orcid.org/0000-0002-5569-9459)
- Elvira Hermawati (ORCID: https://orcid.org/0000-0002-5492-3316)
Institutions
- Bandung Institute of Technology (ID)
- University of Bangka Belitung (ID)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00377f
- Citations
- 3
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Lembaga Pengelola Dana Pendidikan