Insulin‐Like Growth Factor 1 Receptor Expression for Predicting PD‑1/PD‑L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma
IGF-1R expression could potentially serve as a better predictor of PD-1/PD-L1 inhibitor response rate in patients with HPSCC compared to p16 status. Combination therapy using IGF-1R inhibitors and PD-1/PD-L1 blockade may prove to be an effective treatment approach for patients with p16+ HPSCC.
Authors
- Ming Liu (ORCID: https://orcid.org/0000-0002-5957-0142)
- Yu Dong (ORCID: https://orcid.org/0000-0002-5942-6239)
- Xiaolin Xu (ORCID: https://orcid.org/0000-0001-8393-2783)
- Pengjun Liu
- Linli Tian
- SHAO-NENG WANG
- Lei Ye (ORCID: https://orcid.org/0000-0001-9055-1874)
- Yi Wang (ORCID: https://orcid.org/0000-0003-0797-5209)
- Wenjing Li (ORCID: https://orcid.org/0000-0002-8303-7604)
- Xiaoli Ren (ORCID: https://orcid.org/0009-0005-1656-0840)
- Li‐Cheng Xu
Institutions
- Harbin Medical University (CN)
- Guangxi Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- World Journal of Otorhinolaryngology - Head and Neck Surgery
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/wjo2.70025
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China