Synthesis of Substituted 3‐Allyl‐1‐Methylindolin‐2‐Ones by Palladium‐Catalyzed Cyclization of N‐(2‐Iodophenyl)‐N‐Methylbicyclo[1.1.0]Butane‐1‐Carboxamides
As a novel class of reactive electrophiles, bicyclo[1.1.0]butanes (BCB) remain relatively underexplored. Herein, a palladium‐catalyzed reaction of bicyclo[1.1.0]butanes is disclosed that provides a variety of 3‐allylindolin‐2‐ones in moderate‐to‐excellent yields with very good functional group tolerance. This protocol features mild reaction conditions and broad substrate scope.
Authors
- Wei Guo (ORCID: https://orcid.org/0000-0002-4456-3927)
- Yongdong Li (ORCID: https://orcid.org/0000-0001-8756-0438)
- Anzhi Li
- Jiali Lin
- Shuyu Jia (ORCID: https://orcid.org/0000-0002-9054-8584)
- Jiayi Shen (ORCID: https://orcid.org/0000-0001-5604-7973)
- Sheng Chen (ORCID: https://orcid.org/0000-0003-3526-7808)
- Zhiyong Tan
Institutions
- Gannan Normal University (CN)
- Jiangxi College of Applied Technology (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/ejoc.202500321
- Citations
- 1
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China