Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents

Our findings highlight that gut microbiota alterations contribute to AAs deficiency, particularly lysine, which plays a crucial role in MDD pathogenesis in children and adolescents. Targeting AA metabolism may offer novel therapeutic strategies for pediatric depression. Video Abstract.

Authors

Institutions

Publication Details

Journal
Microbiome
Published
2025-05-19
DOI
https://doi.org/10.1186/s40168-025-02122-w
Citations
11
Primary Topic
Diet and metabolism studies
Type
article
Field-Weighted Citation Impact
12.81

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents

Xinyu Zhou, Jing Sui, Chenhong Zhang, Bangmin Yin et al.
11 citations
Microbiome
Diet and metabolism studies
12.81
article

Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents

Xinyu Zhou, Jing Sui, Chenhong Zhang, Bangmin Yin, Zheng‐Jiang Zhu, Kai Guo, Yuping Cai, Xiaofei Yu, Ming Xu, Lige Zhang, Aijing Geng, Luman Zhang, Chengzhi Chen, Xuemei Li, Teng Teng, Fei Chen, Jushuang Zhang, Fang Huang
article en
11 citations

Abstract

Our findings highlight that gut microbiota alterations contribute to AAs deficiency, particularly lysine, which plays a crucial role in MDD pathogenesis in children and adolescents. Targeting AA metabolism may offer novel therapeutic strategies for pediatric depression. Video Abstract.

MicrobiomeVol. 13(1)
China Mobile (China) (CN), Fudan University (CN), Beijing Normal University (CN), Shanghai Institute of Organic Chemistry (CN), Chinese Institute for Brain Research (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Public Health Medical Center (CN), Chongqing Medical University (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Chongqing, Centre Scientifique et Technique du Bâtiment, National Key Research and Development Program of China
Openalex Percentile: Top 1%
Diet and metabolism studies
12.81
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.