Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents
Our findings highlight that gut microbiota alterations contribute to AAs deficiency, particularly lysine, which plays a crucial role in MDD pathogenesis in children and adolescents. Targeting AA metabolism may offer novel therapeutic strategies for pediatric depression. Video Abstract.
Authors
- Xinyu Zhou (ORCID: https://orcid.org/0000-0003-1908-0357)
- Jing Sui (ORCID: https://orcid.org/0000-0002-3997-8968)
- Chenhong Zhang (ORCID: https://orcid.org/0000-0002-4462-892X)
- Bangmin Yin
- Zheng‐Jiang Zhu (ORCID: https://orcid.org/0000-0002-3272-3567)
- Kai Guo (ORCID: https://orcid.org/0009-0008-6665-8792)
- Yuping Cai (ORCID: https://orcid.org/0000-0002-5701-3609)
- Xiaofei Yu (ORCID: https://orcid.org/0000-0002-1712-331X)
- Ming Xu (ORCID: https://orcid.org/0000-0001-5234-2203)
- Lige Zhang (ORCID: https://orcid.org/0009-0002-3845-0413)
- Aijing Geng
- Luman Zhang
- Chengzhi Chen (ORCID: https://orcid.org/0000-0002-1087-4911)
- Xuemei Li (ORCID: https://orcid.org/0000-0002-5966-6240)
- Teng Teng (ORCID: https://orcid.org/0000-0003-3701-0002)
- Fei Chen (ORCID: https://orcid.org/0009-0000-0846-537X)
- Jushuang Zhang
- Fang Huang (ORCID: https://orcid.org/0000-0001-5171-145X)
Institutions
- China Mobile (China) (CN)
- Fudan University (CN)
- Beijing Normal University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Chinese Institute for Brain Research (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s40168-025-02122-w
- Citations
- 11
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 12.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment
- National Key Research and Development Program of China