Increased Recall of Negative Memories Following Initial Methylphenidate Administration in a 6‐Year‐Old Boy With <scp>ADHD</scp>: A Case Report

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that begins in childhood and can persist into adolescence and adulthood. Stimulants, particularly methylphenidate and amphetamines, are the first-line treatments for ADHD in children and adolescents. While the potential for stimulants to induce psychosis-like or mania-like symptoms in children has been recognized for decades, there have been no reported cases of increased recall of negative memories associated with methylphenidate. Here, we present a rare case in which an initial dose of 18 mg of Methylphenidate Hydrochloride Extended-Release Tablets led to increased recall of negative life events in a 6-year-old child with ADHD. Interestingly, the symptom resolved spontaneously the following day without discontinuing the medication, suggesting that it was an adaptive response rather than a toxic reaction.

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Journal
Neuropsychopharmacology Reports
Published
2025-05-19
DOI
https://doi.org/10.1002/npr2.70026
Primary Topic
Attention Deficit Hyperactivity Disorder
Type
article
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article

Increased Recall of Negative Memories Following Initial Methylphenidate Administration in a 6‐Year‐Old Boy With ADHD: A Case Report

Youguo Tan, Qingqing Xiang, A. Ye, Yiguo Feng et al.
Neuropsychopharmacology Reports
Attention Deficit Hyperactivity Disorder
article

Increased Recall of Negative Memories Following Initial Methylphenidate Administration in a 6‐Year‐Old Boy With ADHD: A Case Report

Youguo Tan, Qingqing Xiang, A. Ye, Yiguo Feng, Bo Liu, Liling Xu
article en

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that begins in childhood and can persist into adolescence and adulthood. Stimulants, particularly methylphenidate and amphetamines, are the first-line treatments for ADHD in children and adolescents. While the potential for stimulants to induce psychosis-like or mania-like symptoms in children has been recognized for decades, there have been no reported cases of increased recall of negative memories associated with methylphenidate. Here, we present a rare case in which an initial dose of 18 mg of Methylphenidate Hydrochloride Extended-Release Tablets led to increased recall of negative life events in a 6-year-old child with ADHD. Interestingly, the symptom resolved spontaneously the following day without discontinuing the medication, suggesting that it was an adaptive response rather than a toxic reaction.

Neuropsychopharmacology ReportsVol. 45(2)
Southwest Medical University (CN), Zigong First People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 86%
Attention Deficit Hyperactivity Disorder
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