Association of Elevated Serum <scp>S100A8</scp> / <scp>A9</scp> Levels and Cognitive Impairment in Patients With Systemic Lupus Erythematosus
In this large cohort of patients with well-characterized SLE, serum S100A8/A9 levels were elevated in those with CI and showed an inverse relationship with cognitive performance across multiple domains. Changes in S100A8/A9 levels corresponded with changes in cognitive status over one year. These findings warrant further investigation into the role of S100A8/A9 in CI within the context of SLE.
Authors
- Zahi Touma (ORCID: https://orcid.org/0000-0001-5177-2076)
- Lesley Ruttan (ORCID: https://orcid.org/0000-0002-6431-5023)
- Michelle Barraclough (ORCID: https://orcid.org/0000-0002-9698-0917)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Dorcas Beaton (ORCID: https://orcid.org/0000-0002-5636-8766)
- May Y. Choi (ORCID: https://orcid.org/0000-0003-3760-2737)
- Joan Wither
- Dafna D. Gladman (ORCID: https://orcid.org/0000-0002-9074-0592)
- Patricia Katz (ORCID: https://orcid.org/0000-0002-8146-2519)
- Roberta Pozzi Kretzmann (ORCID: https://orcid.org/0000-0001-9119-3714)
- Kathleen S. Bingham (ORCID: https://orcid.org/0000-0002-4539-220X)
- Carolina Muñoz‐Grajales (ORCID: https://orcid.org/0000-0001-7889-0881)
- Robin Green (ORCID: https://orcid.org/0000-0001-9451-3963)
- Mahta Kakvan
- Simone Appenzeller (ORCID: https://orcid.org/0000-0001-5075-4474)
- Sherief Marzouk (ORCID: https://orcid.org/0000-0002-1986-6854)
- Jiandong Su (ORCID: https://orcid.org/0000-0002-4303-9699)
- Juan Pablo Díaz-Martínez
- Dennisse Bonilla
Institutions
- University Health Network (CA)
- University of Calgary (CA)
- University of California, San Francisco (US)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Manchester Academic Health Science Centre (GB)
- Toronto Rehabilitation Institute (CA)
- Manchester University NHS Foundation Trust (GB)
- Krembil Foundation (CA)
- Institute for Work & Health (CA)
- NIHR Manchester Biomedical Research Centre (GB)
- Krembil Research Institute
- University of Manitoba (CA)
Publication Details
- Journal
- Arthritis Care & Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/acr.25575
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Lupus Research Alliance
- Arthritis Society
- University of Toronto
- Canadian Institutes of Health Research
- Department of Medicine, University of Toronto