Molecular Profiling and Tumor Microenvironment in Sinonasal Mucosal Melanoma as Biomarkers for Enhanced Prognostic Stratification
Molecular profiling in SNMM provides prognostic information beyond standard clinical parameters. Cell cycle and immune-related gene expression patterns, together with decreased infiltration of CD4+, CD8+, Th1, and B cells, correlate with poorer MSS. Integrating molecular profiling with clinical staging could improve risk assessment and help identify high-risk patients for tailored therapeutic approaches.
Authors
- Manuel Bernal‐Sprekelsen (ORCID: https://orcid.org/0000-0001-8191-9833)
- Teresa Torres (ORCID: https://orcid.org/0000-0003-3847-2647)
- María Jesús Rojas‐Lechuga (ORCID: https://orcid.org/0000-0002-1402-5167)
- J. Mateu (ORCID: https://orcid.org/0000-0002-0586-1200)
- Isam Alobid (ORCID: https://orcid.org/0000-0001-7204-5599)
- Cristóbal Langdon (ORCID: https://orcid.org/0000-0003-1540-8095)
- Jaume Bagué (ORCID: https://orcid.org/0009-0003-6502-5436)
- Vinícius Gonçalves de Souza (ORCID: https://orcid.org/0000-0002-1656-6928)
- Susana Puig (ORCID: https://orcid.org/0000-0003-1337-9745)
- Manuel Molina-García (ORCID: https://orcid.org/0000-0003-4218-9756)
- R.M. Patricio da Silva-Junior
Institutions
- Hospital Sant Joan de Déu Barcelona (ES)
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Instituto de Salud Carlos III (ES)
- Hospital de Câncer de Barretos (BR)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/alr.23606
- Primary Topic
- Infectious Diseases and Mycology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Instituto de Salud Carlos III