Remote‐Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model
Abstract Wound healing is a significant opportunity in biomedical science, requiring precise therapeutic delivery and real‐time monitoring. Bioelectronic devices address this need and require further validation in large animal models that reflect human healing dynamics. This work introduces a wireless, remotely controlled bioelectronic platform with an iontophoretic pump to deliver fluoxetine, a selective serotonin reuptake inhibitor that modulates inflammation and promotes wound repair. Treatment over 3 days in a porcine model increased re‐epithelialization by 37% and reduced inflammation, as shown by a 33% decrease in the ratio of pro‐inflammatory M1 macrophages to pro‐reparative M2 macrophages compared to controls. The platform accelerated early wound healing and stimulated neuronal growth at the wound site.
Authors
- Min Zhao (ORCID: https://orcid.org/0000-0002-2500-3035)
- Anthony Gallegos (ORCID: https://orcid.org/0000-0003-1667-9065)
- Marco Rolandi (ORCID: https://orcid.org/0000-0001-7898-2479)
- Mircea Teodorescu (ORCID: https://orcid.org/0000-0001-7085-5248)
- R. Rivkah Isseroff (ORCID: https://orcid.org/0000-0001-7813-0858)
- Karthik Devarajan (ORCID: https://orcid.org/0000-0002-8475-383X)
- Tiffany Nguyen (ORCID: https://orcid.org/0000-0003-1088-7840)
- Houpu Li (ORCID: https://orcid.org/0000-0001-9698-8911)
- Kan Zhu (ORCID: https://orcid.org/0000-0002-1146-8130)
- Wan Shen Hee
- Cynthia Recendez (ORCID: https://orcid.org/0000-0002-7915-8980)
- Elham Aslankoohi
- Héctor Carrión (ORCID: https://orcid.org/0009-0004-5750-2551)
- Maryam Tebyani (ORCID: https://orcid.org/0000-0001-5477-2805)
- Célia Maria Landi Franco (ORCID: https://orcid.org/0000-0002-4941-1463)
- Marcella Gomez (ORCID: https://orcid.org/0000-0002-4143-5460)
- Narges Asefifeyzabadi (ORCID: https://orcid.org/0000-0001-7134-428X)
- Prabhat Baniya (ORCID: https://orcid.org/0000-0002-5041-3407)
- Hsin‐ya Yang (ORCID: https://orcid.org/0000-0002-5325-494X)
- Narges Norouzi (ORCID: https://orcid.org/0000-0001-9861-7540)
- Alexie Barbee (ORCID: https://orcid.org/0009-0008-9446-3722)
- Kaelan Schorger
- Sydnie Figuerres
- Fan Lu (ORCID: https://orcid.org/0000-0001-6490-6416)
- Sujung Kim (ORCID: https://orcid.org/0000-0002-7455-2866)
- George Luka
Institutions
- University of California, Santa Cruz (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Advanced Materials Technologies
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/admt.202500040
- Citations
- 8
- Primary Topic
- Planarian Biology and Electrostimulation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- U.S. Department of the Interior
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- Interior Business Center
- Defense Sciences Office, DARPA