Neutrophils predominate as IL1B-expressing cells in Schnitzler syndrome: Insights from the SCan study to evaluate the efficacy and safety of canakinumab in Japanese patients
This study demonstrated that the primary source of IL1B-expressing cells in SchS is neutrophils. Moreover, canakinumab improves clinical symptoms by regulating neutrophil dynamics in peripheral blood.
Authors
- Norimitsu Inoue (ORCID: https://orcid.org/0000-0002-1226-5183)
- Yoko Amino
- Satoru Yonekura (ORCID: https://orcid.org/0000-0003-4047-3016)
- Nobuo Kanazawa (ORCID: https://orcid.org/0000-0003-3000-9711)
- K. Takemura (ORCID: https://orcid.org/0000-0003-2425-4876)
- Yadong Zhou (ORCID: https://orcid.org/0000-0003-3357-3553)
- Tomoyasu Jo (ORCID: https://orcid.org/0000-0001-9381-0421)
- Hajime Yoshifuji (ORCID: https://orcid.org/0000-0001-7082-4900)
- Satoshi Nakamizo (ORCID: https://orcid.org/0000-0001-9332-0369)
- Naotomo Kambe (ORCID: https://orcid.org/0000-0001-9610-4952)
- Katsuki Ohtani
- Mayuko Yamamoto
- Shin‐ichiro Kagami (ORCID: https://orcid.org/0000-0001-9439-8918)
- Yoshie Kawahara (ORCID: https://orcid.org/0000-0001-7611-1557)
- Kazushi Izawa (ORCID: https://orcid.org/0000-0003-1080-0936)
- Yoko Ueki
- Kosuke Katsuo
- Yumiko Ibi
- Hiroshi Tsujimoto (ORCID: https://orcid.org/0000-0001-5579-6526)
- Satoshi Morita (ORCID: https://orcid.org/0000-0002-4344-3317)
Institutions
- Hyogo Medical University (JP)
- Wakayama Medical University (JP)
- Kyoto University (JP)
- Asahi General Hospital (JP)
- keiyu Hospital (JP)
- Kyoto University Hospital (JP)
- Kōchi University (JP)
- Rakuno Gakuen University (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.alit.2025.04.003
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Japan Agency for Medical Research and Development