Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy
These findings advance surgical planning by demonstrating that quantitative spike analysis can effectively supplement seizure data in localizing mesial temporal lobe epilepsy. This approach could reduce reliance on prolonged seizure monitoring, potentially decreasing patient risk and hospitalization costs while improving surgical targeting. Our results support incorporating automated spike analysis into standard clinical workflows for epilepsy surgery evaluation.
Authors
- Alfredo Lucas (ORCID: https://orcid.org/0000-0001-9439-735X)
- Brian Litt (ORCID: https://orcid.org/0000-0003-2732-6927)
- Joshua J. LaRocque (ORCID: https://orcid.org/0000-0002-3697-9965)
- Devin Ma (ORCID: https://orcid.org/0009-0002-0426-7960)
- Saurabh R. Sinha (ORCID: https://orcid.org/0000-0003-0305-6731)
- Colin A. Ellis (ORCID: https://orcid.org/0000-0003-2152-8106)
- Erin C. Conrad (ORCID: https://orcid.org/0000-0001-8910-1817)
- Ezequiel L. Gleichgerrcht (ORCID: https://orcid.org/0000-0002-4212-4146)
- Alexandra Parashos (ORCID: https://orcid.org/0009-0005-8627-8306)
- Akash R. Pattnaik (ORCID: https://orcid.org/0000-0002-2474-1685)
- Kathryn A. Davis (ORCID: https://orcid.org/0000-0002-7020-6480)
- William K.S. Ojemann (ORCID: https://orcid.org/0009-0007-5166-536X)
- Carlos A. Aguila (ORCID: https://orcid.org/0009-0003-9460-3549)
- Mariam Josyula
- Nina Petillo
- Juri Kim
- Sarah B. Lavelle (ORCID: https://orcid.org/0009-0000-8704-9445)
Institutions
- Emory University (US)
- Medical University of South Carolina (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/epi.18462
- Citations
- 3
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Science Foundation
- Burroughs Wellcome Fund
- Georgia Clinical and Translational Science Alliance
- Mirowski Family Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke