<scp>IFNγ</scp> Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy
Bregs play an immunoregulatory role during EoE by controlling esophageal eosinophilia but are functionally impaired due to IFNγ-mediated signaling. These findings have important implications for understanding EoE's etiology and implementing future therapies that target IFNγ.
Authors
- Eric Rodriguez-Lopez
- David A. Hill (ORCID: https://orcid.org/0000-0001-9286-4268)
- Rachel L. Clement (ORCID: https://orcid.org/0000-0003-1422-9140)
- Cleandre M. Guerrier
- Julie Dilollo
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Allergy
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/all.16594
- Citations
- 3
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- American Academy of Allergy Asthma and Immunology
- Children's Hospital of Philadelphia
- Hartwell Foundation
- University of Pennsylvania
- American Partnership for Eosinophilic Disorders
- National Institutes of Health
- American Academy of Allergy, Asthma and Immunology Foundation