Patients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients
NORSE and SE patients present with a more variable and dramatically different fecal microbiome than chronic epilepsy patients, which may indicate gut dysbiosis that may be reciprocally linked to inflammatory responses. Although NORSE and SE patients had similar microbiome structures, fungal and bacterial correlates with inflammatory cytokines differed between NORSE and SE, with confounding factors influencing microbiome structure. Our data suggest a microbiome-specific response to NORSE and SE, with implications for future treatment strategies.
Authors
- Nicolas Gaspard (ORCID: https://orcid.org/0000-0003-1148-6723)
- Orrin Devinsky (ORCID: https://orcid.org/0000-0003-0044-4632)
- Onome Eka (ORCID: https://orcid.org/0000-0002-4294-8292)
- Aurélie Hanin (ORCID: https://orcid.org/0000-0002-5912-9998)
- Deepak Saxena (ORCID: https://orcid.org/0000-0002-5506-5827)
- Maria Pleshkevich (ORCID: https://orcid.org/0000-0002-4888-2415)
- Marissa Kellogg (ORCID: https://orcid.org/0000-0001-7809-7082)
- Ji Yeoun Yoo (ORCID: https://orcid.org/0000-0001-7242-9779)
- Sung Wook Hwang (ORCID: https://orcid.org/0000-0002-6981-7575)
- Fangxi Xu (ORCID: https://orcid.org/0000-0002-4265-2133)
- Alexandra Martín Ramírez (ORCID: https://orcid.org/0000-0002-1132-2211)
- Brandon Foreman (ORCID: https://orcid.org/0000-0002-5418-674X)
- Claude Steriade (ORCID: https://orcid.org/0000-0001-6799-9005)
- Lawrence J. Hirsch (ORCID: https://orcid.org/0000-0002-6333-832X)
- Mark S. Wainwright (ORCID: https://orcid.org/0000-0002-4736-7462)
- Scott C. Thomas (ORCID: https://orcid.org/0000-0001-5140-6033)
- Amit Ahituv
- Audrey Oliger (ORCID: https://orcid.org/0009-0003-8424-3885)
- M. Morales
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Inserm (FR)
- Neurosciences Institute (US)
- University of Washington (US)
- Yale University (US)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut du Cerveau (FR)
- New York University (US)
- University of Cincinnati (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/epi.18450
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Organization for Rare Disorders
- Epilepsy Society