Identifying a unique signature of sepsis in patients with pre-existing cirrhosis
We identified associations between pre-existing cirrhosis and endothelial injury, AKI, and mortality in sepsis. Patients with pre-existing cirrhosis who develop sepsis may display a unique phenotype of endothelial dysfunction that requires unique targeted approaches.
Authors
- R. Avery Bennett (ORCID: https://orcid.org/0000-0002-5210-1386)
- M.G.S. Shashaty (ORCID: https://orcid.org/0000-0002-8766-3418)
- C.A.G. Ittner
- Anushka Dasgupta (ORCID: https://orcid.org/0009-0006-2314-3604)
- Todd A. Miano (ORCID: https://orcid.org/0000-0002-3832-6212)
- Nuala J. Meyer (ORCID: https://orcid.org/0000-0003-4597-5584)
- Brian J. Anderson (ORCID: https://orcid.org/0000-0002-2426-9683)
- Tiffanie K. Jones (ORCID: https://orcid.org/0000-0003-0058-8847)
- H.M. Giannini (ORCID: https://orcid.org/0000-0002-8979-3806)
- Gulus Emre
- K.C. Housel
- John P. Reilly (ORCID: https://orcid.org/0000-0003-3937-5320)
- Alexandra P. Turner (ORCID: https://orcid.org/0000-0003-3577-8587)
- MIKA ESPERANZA
- Matthew Erlich
Institutions
- University of the Sciences (US)
- Translational Therapeutics (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Critical Care
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13054-025-05423-6
- Citations
- 2
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- University of Pennsylvania
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- NIH Office of the Director