<i>Mycobacterium tuberculosis</i> bacillus induces pyroptosis in human lung fibroblasts

The role of "non-classical immune cells," that is, fibroblasts, epithelial cells, adipocytes, etc., except for the "classical immune cells," that is, macrophages and lymphoid cells, is not well known in the infection of Mtb bacilli. We have previously found that live, but not dead, Mtb bacilli induce cell death in human lung fibroblasts, except in human macrophages and monocytes. The present study reveals that fibroblasts ingest Mtb bacilli the same as macrophages and that <i>in vivo</i> Mtb bacilli within fibroblasts attempt to survive in the host cells, and pyroptosis, including the production of inflammatory cytokines, is induced in the Mtb-infected fibroblasts. Our results suggest that pyroptosis of the host fibroblasts activates the immune system against the infection.

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Publication Details

Journal
mSphere
Published
2025-05-19
DOI
https://doi.org/10.1128/msphere.00110-25
Citations
2
Primary Topic
Inflammasome and immune disorders
Type
article
Field-Weighted Citation Impact
1.61

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article

Mycobacterium tuberculosis bacillus induces pyroptosis in human lung fibroblasts

Joanne Turner, Jordi Bertran Torrelles, Naoya Ohara, Hidetoshi Hayashi et al.
2 citations
mSphere
Inflammasome and immune disorders
1.61
article

Mycobacterium tuberculosis bacillus induces pyroptosis in human lung fibroblasts

Joanne Turner, Jordi Bertran Torrelles, Naoya Ohara, Hidetoshi Hayashi, Chihiro Motozono, Takemasa Takii, Hiroyuki Yamada, Yukihiro Asami, Aoi Kimishima, Shigeaki Hida, Sho Yamasaki, Kikuo Onozaki
article en
2 citations

Abstract

The role of "non-classical immune cells," that is, fibroblasts, epithelial cells, adipocytes, etc., except for the "classical immune cells," that is, macrophages and lymphoid cells, is not well known in the infection of Mtb bacilli. We have previously found that live, but not dead, Mtb bacilli induce cell death in human lung fibroblasts, except in human macrophages and monocytes. The present study reveals that fibroblasts ingest Mtb bacilli the same as macrophages and that <i>in vivo</i> Mtb bacilli within fibroblasts attempt to survive in the host cells, and pyroptosis, including the production of inflammatory cytokines, is induced in the Mtb-infected fibroblasts. Our results suggest that pyroptosis of the host fibroblasts activates the immune system against the infection.

mSphereVol. 10(6)
Texas Biomedical Research Institute (US), Okayama University (JP), Nagoya City University (JP), Japan Anti Tuberculosis Association (JP), Biomedical Research Institute (US), Kitasato University (JP), Kumamoto University (JP), The University of Osaka (JP)
Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 17%
Inflammasome and immune disorders
1.61
DOIOpen Access PDFOpenAlex
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<i>Mycobacterium tuberculosis</i> bacillus induces pyroptosis in human lung fibroblasts — Joanne Turner, Jordi Bertran Torrelles, et al. · mSphere (2025) | TGRS Research Map | TGRS