One Health study of mobile colistin resistance ( <i>mcr</i> ) in <i>Salmonella enterica</i> in Canada, 2017–2022
Colistin can be used in combination with other drugs as salvage therapy for extensively drug-resistant infections. If mobile colistin resistance (<i>mcr</i>) becomes widely disseminated in <i>Enterobacterales</i>, colistin will no longer be an option for salvage therapy in otherwise untreatable infections. While colistin is not commonly used to treat human <i>Salmonella</i> infections, <i>Salmonella</i> represents an important reservoir of <i>mcr</i> genes that may be transmitted to other gram-negative bacteria. Our aim was to determine the occurrence of <i>mcr</i> genes in <i>Salmonella</i> isolates collected from humans, food animals, and retail meats in Canada.
Authors
- Linda Chui (ORCID: https://orcid.org/0000-0003-0851-9803)
- Tanis C. Dingle (ORCID: https://orcid.org/0000-0002-6936-406X)
- Audrey Charlebois (ORCID: https://orcid.org/0000-0002-4609-0254)
- David Thumbi
- Xiaofeng Ding (ORCID: https://orcid.org/0000-0002-7319-6441)
- Linda Hoang (ORCID: https://orcid.org/0000-0001-7769-6120)
- Amrita Bharat (ORCID: https://orcid.org/0000-0003-4171-9436)
- Anne Deckert (ORCID: https://orcid.org/0000-0002-6283-1999)
- Carolee A. Carson (ORCID: https://orcid.org/0000-0003-2712-0961)
- Xiao Rui Li
- Ketna Mistry
- Jessica Minion (ORCID: https://orcid.org/0000-0002-8863-5697)
- Sameh El Bailey
- David C. Alexander (ORCID: https://orcid.org/0000-0003-3509-445X)
- Sadjia Békal (ORCID: https://orcid.org/0000-0001-9840-0114)
- George Zahariadis
- David Haldane
- Sara Christianson
- Ashley C. Cormier (ORCID: https://orcid.org/0000-0001-5169-3693)
- Samir N. Patel (ORCID: https://orcid.org/0000-0001-9824-7623)
- Colleen Murphy (ORCID: https://orcid.org/0000-0003-3294-5028)
- Jennifer Campbell
- Ashley Kearney
- Michael R. Mulvey
- Brent P. Avery
- Richard J. Reid‐Smith
- Céline Nadon
Institutions
- University of Alberta (CA)
- University of Calgary (CA)
- Public Health Agency of Canada (CA)
- Saskatchewan Health Authority (CA)
- Saskatchewan Health (CA)
- Queen Elizabeth II Health Sciences Centre (CA)
- Horizon Health Network (CA)
- Government of Newfoundland and Labrador (CA)
- BC Centre for Disease Control (CA)
- Public Health Ontario (CA)
- Taiwan Centers for Disease Control (TW)
- Public Health Laboratory
- University of Manitoba (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1128/spectrum.02156-24
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59