Activation of NF–κB Signaling by a High-Fat and High-Sugar Diet Enhances Macrophage Polarization and Aggravates Postoperative Pain and Inflammatory Responses

An HFHS diet exacerbates postoperative pain and inflammation via NF-κB activation and M1 macrophage polarization. Inhibiting NF-κB may mitigate diet-induced sensitization.

Authors

Publication Details

Journal
Immunological Investigations
Published
2025-05-19
DOI
https://doi.org/10.1080/08820139.2025.2505900
Citations
2
Primary Topic
Cancer, Stress, Anesthesia, and Immune Response
Type
article
Field-Weighted Citation Impact
2.94
Controls
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article

Activation of NF–κB Signaling by a High-Fat and High-Sugar Diet Enhances Macrophage Polarization and Aggravates Postoperative Pain and Inflammatory Responses

Ming Zhu, Chenran Zhang
2 citations
Immunological Investigations
Cancer, Stress, Anesthesia, and Immune Response
2.94
article

Activation of NF–κB Signaling by a High-Fat and High-Sugar Diet Enhances Macrophage Polarization and Aggravates Postoperative Pain and Inflammatory Responses

Ming Zhu, Chenran Zhang
article en
2 citations

Abstract

An HFHS diet exacerbates postoperative pain and inflammation via NF-κB activation and M1 macrophage polarization. Inhibiting NF-κB may mitigate diet-induced sensitization.

Immunological InvestigationsVol. 54(6)
Zero hunger
Openalex Percentile: Top 10%
Cancer, Stress, Anesthesia, and Immune Response
2.94
DOISourceOpenAlex
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Activation of NF–κB Signaling by a High-Fat and High-Sugar Diet Enhances Macrophage Polarization and Aggravates Postoperative Pain and Inflammatory Responses — Ming Zhu, Chenran Zhang · Immunological Investigations (2025) | TGRS Research Map | TGRS