DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway
In our study, we demonstrated that TET2 deficiency aggravates endothelial cell dysfunction and promotes acute lung injury by targeting ITGA10 via the PI3K-AKT pathway. These findings indicate that TET2 may be a promising therapeutic target for treating sepsis-induced ALI.
Authors
- Xin Zhou (ORCID: https://orcid.org/0000-0002-7184-1101)
- Ailin Lan (ORCID: https://orcid.org/0000-0002-3649-1011)
- Bin Gao (ORCID: https://orcid.org/0000-0003-3769-0191)
- Yingting Hao
- Jingyi Tang (ORCID: https://orcid.org/0000-0002-8754-5809)
- Liu Chang
- Fachun Zhou
- Hongxue Fu
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s11658-025-00739-1
- Citations
- 4
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Chongqing University
- Chongqing Medical University