Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models
Lipid metabolism, particularly seven key lipoprotein subfractions, has been identified as a major risk factor for high-FNPO PCOS cases. Among these, V3TG subfraction warrants special attention, both from the perspective of disease risk and precision diagnosis. Due to the lack of effective external validation at this stage, validation of larger sample sizes is necessary before generalizing the application.
Authors
- Shigang Zhao (ORCID: https://orcid.org/0000-0002-7407-9220)
- Xueqi Yan (ORCID: https://orcid.org/0000-0003-0799-6624)
- Xueying Gao (ORCID: https://orcid.org/0000-0002-5868-5378)
- Han Zhao (ORCID: https://orcid.org/0000-0001-9515-7534)
- Shumin Li (ORCID: https://orcid.org/0000-0003-1351-4839)
- Jinlong Ma (ORCID: https://orcid.org/0000-0002-4288-6327)
- Ziyi Yang (ORCID: https://orcid.org/0009-0004-8743-8466)
- Yimeng Li (ORCID: https://orcid.org/0000-0002-5658-3706)
- Yu Sun (ORCID: https://orcid.org/0000-0002-2009-779X)
- Hui Zhao (ORCID: https://orcid.org/0000-0002-5462-7365)
- Gengchen Feng
Institutions
- Shandong University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Renji Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12916-025-04120-z
- Citations
- 2
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China