Chronic High‐Fat Diet Consumption Followed by Lipopolysaccharide Challenge Induces Persistent and Long‐Lasting Microglial Priming, Mediates Synaptic Elimination via Complement C1q, and Leads to Behavioral Abnormalities in Male Wistar Rats
HFD consumption persistently and time-dependently primes microglia similar to a single LPS injection, influencing immune responses and contributing to behavioral abnormalities.
Authors
- Nipon Chattipakorn (ORCID: https://orcid.org/0000-0003-3026-718X)
- Titikorn Chunchai (ORCID: https://orcid.org/0000-0003-4405-1208)
- Busarin Arunsak (ORCID: https://orcid.org/0000-0002-5120-288X)
- Nattayaporn Apaijai (ORCID: https://orcid.org/0000-0002-1265-5210)
- Hiranya Pintana
- Chanisa Thonusin (ORCID: https://orcid.org/0000-0003-4984-8769)
- Jirapas Sripetchwandee (ORCID: https://orcid.org/0000-0002-4473-7018)
- Sasiwan Kerdphoo
- Chanon Kunasol (ORCID: https://orcid.org/0000-0003-1744-0005)
- Siriporn C. Chattipakorn (ORCID: https://orcid.org/0000-0003-1677-7052)
- Patcharapong Pantiya (ORCID: https://orcid.org/0000-0002-2181-7197)
- Wichwara Nawara
- Suriphan Donchada
Institutions
- Chiang Mai University (TH)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/apha.70060
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Chiang Mai University
- National Research Council of Thailand