Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival
Collectively, our results demonstrate that AML cells critically depend on LDHA to maintain an adequate NAD<sup>+</sup>/NADH balance in support of their abnormal glycolytic activity and biosynthetic demands, which cannot be compensated for by other cellular NAD<sup>+</sup> recycling systems. These findings also highlight LDHA inhibition as a promising metabolic strategy to eradicate leukemic cells.
Authors
- Guido T. Bommer (ORCID: https://orcid.org/0000-0001-6898-4884)
- Jan Jacob Schuringa (ORCID: https://orcid.org/0000-0001-8452-8555)
- Francesco Caligiore (ORCID: https://orcid.org/0000-0002-4038-3136)
- Keisuke Ito (ORCID: https://orcid.org/0000-0002-6702-9735)
- Fleur Leguay
- Manuel Johanns (ORCID: https://orcid.org/0000-0003-2536-5949)
- Ayşegül Erdem
- Nick van Gastel (ORCID: https://orcid.org/0000-0002-0563-3590)
- S.B. Kaye
Institutions
- Albert Einstein College of Medicine (US)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Montefiore Health System (US)
- de Duve Institute (BE)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s40170-025-00392-4
- Citations
- 11
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 19.47
Funders
- Leukemia and Lymphoma Society
- Université Catholique de Louvain
- ZonMw
- Fonds De La Recherche Scientifique - FNRS
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Akademie Věd České Republiky
- Fondation contre le Cancer
- National Institutes of Health