Upregulated NOTCH2 Expression Is Implicated in the Clinical Aggressiveness of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma
Upregulated NOTCH2 expression plays a significant role in disease progression, in part through the canonical signaling pathway involving the downstream effector HES1. Targeting NOTCH2 signaling might hold therapeutic promise in patients with disease progression.
Authors
- Emilia Sorescu
- Thilo Gambichler (ORCID: https://orcid.org/0000-0001-7862-3695)
- Yi‐Pei Lee (ORCID: https://orcid.org/0000-0002-2495-6176)
- Markus Stücker (ORCID: https://orcid.org/0000-0001-5564-5285)
- Fahimeh Razegphpour
Institutions
- Witten/Herdecke University (DE)
- St. Josef-Hospital (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- International Journal of Dermatology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/ijd.17844
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00