Genomic characteristics of the multiresistant <i>Acinetobacter baumannii</i> global clone 1 reference strain A297/RUH875
The complete genome of RUH875 (A297) consists of a 3 965 450 bp chromosome and three plasmids: pA297-1 (pRAY*; 6078 bp), pA297-2 (8731 bp) and pA297-3 (a 200 kb conjugative plasmid). The chromosome harbours the AbaR21 genomic resistance island, carrying seven antibiotic resistance genes and six prophage regions. Notably, bap1 and bap2, biofilm-associated genes, were fully resolved, with bap1 identical to that of A. baumannii A1-the earliest GC1 isolate. Comparative analysis with A1 revealed 122 SNPs, with clustered variations suggesting potential recombination events. Phylogenetic analysis confirmed A297/RUH875 as a distinct lineage within GC1. The completed genome sequence provides a reference, in addition to strain A1, for studying AMR evolution in GC1 and enhances comparative genomic analyses.
Authors
- Mohammad Hamidian (ORCID: https://orcid.org/0000-0002-3614-7261)
- Ruth M. Hall (ORCID: https://orcid.org/0000-0003-2062-3312)
- Jonathan Koong
Institutions
- University of Technology Sydney (AU)
- The University of Sydney (AU)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1093/jac/dkaf160
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Technology Sydney