Comparison of Phasic Store‐Operated Calcium Entry in Rat Slow‐ and Fast‐Twitch Muscle Fibers
These findings reveal a novel, fiber-type-specific difference in pSOCE regulation. When compared to EDL fibers, soleus fibers exhibited a higher sensitivity to SOCE activation despite releasing less Ca<sup>2+</sup> from the sarcoplasmic reticulum upon an action potential. These differences may allow soleus fibers to sustain Ca<sup>2+</sup> homeostasis more effectively, be more resilient against disruptions in Ca<sup>2+</sup> handling, and entail protection against disease states.
Authors
- Xaver Koenig (ORCID: https://orcid.org/0000-0002-2423-4966)
- Rocky H. Choi
- Bradley S. Launikonis (ORCID: https://orcid.org/0000-0003-0700-4867)
- Elena Lilliu
- Karlheinz Hilber (ORCID: https://orcid.org/0000-0002-3033-0874)
Institutions
- The University of Queensland (AU)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/apha.70059
- Citations
- 2
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund