Anthropometric markers as correlates of metabolically unhealthy phenotype of children in North Asia

Introduction. Stratification of anthropometric indices to identify metabolically unhealthy phenotype in Mongoloid adolescents with different weight status carried out. The aim. T o identify anthropometric parameters that differentiate between metabolically healthy phenotype (MHP) and metabolically unhealthy phenotype (MUHP) in adolescent northern mongoloid populations. Ma t erials and methods. A single-center cross-sectional study conducted in 02.2015–10.2016 in the territory of the Republic of Buryatia and Irkutsk region: anthropometric examination and determination of blood glycemia level, lipidogram analysis, calipometry and measurement of girth parameters. In total 227 children were selected for the study: 137 boys and 90 girls. R esults. All adolescents with metabolically unhealthy phenotyp e had abnormal HDL levels. Comparison of anthropometric paramet ers and indic es in samples of boys with meta bolicdisordersshowedstatisticallysigni fi antdiff encesinWC,HC,WC/HC,subcutaneous fat thickness in all measured locations and roundness index in overweight boys. Comparative analysis of anthropometric parameters and indices in girls of the studied groups did not reveal statistically signifi ant diff ences between girls with MHP and MUHP. The most informative parameters of metabolically unhealthy phenotype in Asian boys are visceral obesity index (AUC = 0.92), SDS BMI (AUC = 0.73), abdominal subcutaneous fat thickness (AUC = 0.73) and on the anterior surface of the upper arm (AUC = 0.74). The optimal SDS BMI cutoff value for predicting metabolic disorders is 2.29 c.u; abdominal subcutaneous fat thickness more than 3.5 cm and on the anterior surface of the upper arm more than 1.0 cm Northern Mongoloid girls had the lar gest areas under the curv e for visc er al ob esit y index ( AUC = 0.84), hip circumference (AUC = 0.7) and taper index (AUC = 0.7). Conclusion. V isc er al adiposity index in adolescents of both sexes is the most informative indicator of metabolic abnormalities. For North Asian boys SDS BMI is a good indicator for verification of metabolically unhealthy phenotype. For girls, hip circumference and taper index can used to screen metabolically unhealthy phenotype.