A protocol for selective synthesis of thiol-functionalized allylic sulfonyl fluorides
An efficient and transition metal-free method has been established for synthesizing a class of novel thiol-functionalized allylic sulfonyl fluorides with exclusive regioselectivity. This method is distinguished by its broad functional group compatibility with up to 99% yield and mild reaction conditions. Additionally, subsequent SuFEx reactions and oxidation processes generated sulfonate, sulfoxide, and sulfone derivatives, which are key motifs in medicinal chemistry, with exceptional efficiency.
Authors
- Hanadi A. Katouah (ORCID: https://orcid.org/0000-0001-9044-2491)
- Eman Elsayed Fayad (ORCID: https://orcid.org/0000-0003-2916-0254)
- Hua‐Li Qin (ORCID: https://orcid.org/0000-0002-6609-0083)
- Monday Peter Ajisafe
- Heba H. Mohamedy
Institutions
- Taif University (SA)
- Wuhan University of Technology (CN)
- Umm al-Qura University (SA)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00487j
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Taif University