Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Compression in liver cancer affects cell states, signaling, and survival, which can be counteracted by inhibiting Rac1 or targeting intracellular calcium as potential avenues to eradicate compression-induced aggressive cancer cells.
Authors
- Dingyao Zhang (ORCID: https://orcid.org/0000-0001-9273-7824)
- Emma Kruglov (ORCID: https://orcid.org/0009-0005-9867-8016)
- Raymond Liu (ORCID: https://orcid.org/0000-0003-4102-8352)
- Ryan Y. Nguyen (ORCID: https://orcid.org/0000-0002-5001-7893)
- M. Fátima Leite (ORCID: https://orcid.org/0000-0001-9709-8865)
- Xiangyu Gong (ORCID: https://orcid.org/0000-0003-4033-9570)
- Barbara E. Ehrlich (ORCID: https://orcid.org/0000-0001-9657-9704)
- Noriyoshi Ogino (ORCID: https://orcid.org/0000-0002-1877-7577)
- Kaitlin Flores (ORCID: https://orcid.org/0000-0002-4746-9565)
- Aidan T. Cabral
- Gabriel Moreira de M. Mendes (ORCID: https://orcid.org/0000-0003-1427-8401)
- Zehua Chen (ORCID: https://orcid.org/0000-0001-6235-9770)
- Michael Mak (ORCID: https://orcid.org/0000-0001-6881-8130)
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Occupational and Environmental Health Japan (JP)
- Yale University (US)
- Stony Brook School (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1158/0008-5472.can-24-0859
- Citations
- 2
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.30