Endocrine chemical disraptors and female reproductive health. Literature review

The review presents data from systematic reviews and metaanalyses addressing the issue of the eff ts of endocrine chemical disraptors (ECDs) on women’s reproductive health. ECDs are defi as exogenous chemicals or combinations of chemicals that aff t any aspect of hormone action and cause adverse health eff ts to the intact organism and/or its off as a result of changes in endocrine function. Currently, the mechanisms of adverse eff ts of many ECDs have been disclosed. It is suggested that ECDs can act as steroid agonists or antagonists by binding to sex steroid receptors. ECDs may also act through non-genomic mechanisms by blocking G protein-coupled receptors. Finally, interference with the action of steroids can contribute to infl through various mechanisms, including the inability to limit the production of reactive oxygen species. This systematic review was contains the most relevant data over the past 5 years on the adverse eff ts of ECD on the health of a woman and her child. Cochrane, MEDLINE, PubMed information bases were evaluated.