Gemcitabine resistance by CITED4 upregulation via the regulation of BIRC2 expression in pancreatic cancer
Collectively, these results indicate that CITED4 regulates GEM resistance via inhibition of apoptosis by upregulating BIRC2 expression in PC cells. Therefore, CITED4 may serve as a valuable diagnostic marker and therapeutic target for GEM-resistant PC.
Authors
- Hyun Seung Ban (ORCID: https://orcid.org/0000-0002-2698-6037)
- Jin-Seong Hwang
- Tae‐Su Han (ORCID: https://orcid.org/0000-0002-9280-5898)
- Eun‐Jeong Jeong (ORCID: https://orcid.org/0009-0008-0745-866X)
- Yuna Roh
- Jang‐Seong Kim
- Eunsun Jung (ORCID: https://orcid.org/0000-0002-5900-6138)
- Taesang Son
- Young‐Kug Choo (ORCID: https://orcid.org/0000-0003-3065-485X)
Institutions
- Konyang University (KR)
- Konyang University Hospital (KR)
- WonKwang Health Science University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Wonkwang University (KR)
- Sungkyunkwan University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12929-025-01140-y
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Research Foundation
- Ministry of Science, ICT and Future Planning
- Korea Research Institute of Bioscience and Biotechnology
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea