A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity

Patients with systemic sclerosis who are anti-Scl-70 antibody negative but Topo I pattern positive may present different clinical manifestations and prognoses, requiring a comprehensive assessment that integrates clinical presentation, laboratory tests, and potential disease progression.

Authors

Publication Details

Journal
Clinical Laboratory
Published
2025-01-01
DOI
https://doi.org/10.7754/clin.lab.2024.241124
Primary Topic
Cytokine Signaling Pathways and Interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity

K Xie, Honggang Sun, Liqin He
Clinical Laboratory
Cytokine Signaling Pathways and Interactions
article

A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity

K Xie, Honggang Sun, Liqin He
article en

Abstract

Patients with systemic sclerosis who are anti-Scl-70 antibody negative but Topo I pattern positive may present different clinical manifestations and prognoses, requiring a comprehensive assessment that integrates clinical presentation, laboratory tests, and potential disease progression.

Clinical LaboratoryVol. 71(05/2025)
Openalex Percentile: Top 83%
Cytokine Signaling Pathways and Interactions
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