Efficacy of encorafenib plus binimetinib in patients with BRAF-mutated melanoma brain metastases: Results from the Dutch Melanoma Treatment Registry

Encorafenib/binimetinib has clinical activity in real-world melanoma patients with BMs. Their prognosis is determined by the presence of symptomatic BMs, age, ECOG PS, and LDH levels.

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Publication Details

Journal
European Journal of Cancer
Published
2025-05-19
DOI
https://doi.org/10.1016/j.ejca.2025.115514
Citations
2
Primary Topic
Melanoma and MAPK Pathways
Type
article
Field-Weighted Citation Impact
1.61

Funders

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article

Efficacy of encorafenib plus binimetinib in patients with BRAF-mutated melanoma brain metastases: Results from the Dutch Melanoma Treatment Registry

Bart Rikhof, Martin W. Bloem, Geke A.P. Hospers, Astrid A M van der Veldt et al.
2 citations
European Journal of Cancer
Melanoma and MAPK Pathways
1.61
article

Efficacy of encorafenib plus binimetinib in patients with BRAF-mutated melanoma brain metastases: Results from the Dutch Melanoma Treatment Registry

Bart Rikhof, Martin W. Bloem, Geke A.P. Hospers, Astrid A M van der Veldt, Willeke A.M. Blokx, Jan Willem B. de Groot, C U Blank, Djura Piersma, A J M van den Eertwegh, Ellen Kapiteijn, Gerard Vreugdenhil, A M Stevense-den Boer, Michel W.J.M. Wouters, Maureen J Aarts, Olivier J. van Not, Karijn P.M. Suijkerbuijk, J.B.A.G. Haanen, Franchette W.P.J. van den Berkmortel, Marye J. Boers‐Sonderen, C D M Boreel
article en
2 citations

Abstract

Encorafenib/binimetinib has clinical activity in real-world melanoma patients with BMs. Their prognosis is determined by the presence of symptomatic BMs, age, ECOG PS, and LDH levels.

European Journal of CancerVol. 223
Leiden University (NL), University Medical Center Groningen (NL), Radboud University Nijmegen (NL), University of Groningen (NL), Utrecht University (NL), Heidelberg University (DE), Maastricht University Medical Centre (NL), Medisch Spectrum Twente (NL), University Hospital Heidelberg (DE), Medisch Centrum Leeuwarden (NL), Radboud University Medical Center (NL), The Netherlands Cancer Institute (NL), University Medical Center Utrecht (NL), Amphia Ziekenhuis (NL), Máxima Medisch Centrum (NL), Zuyderland Medisch Centrum (NL), Isala (NL), Cancer Center Amsterdam (NL), Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Les Laboratories Pierre Fabre
Good health and well-being
Openalex Percentile: Top 17%
Melanoma and MAPK Pathways
1.61
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