Multiomics analysis of umbilical cord hematopoietic stem cells from a multiethnic cohort of Hawaii reveals the intergenerational effect of maternal prepregnancy obesity and risks for cancers
This study revealed the significant correlation between prepregnancy maternal obesity and multiomics-level molecular changes in the uHSCs of offspring, particularly at the DNA methylation level. These maternal-obesity-associated epigenetic markers in uHSCs may contribute to increased risks in certain cancers of the offspring. Larger and multicenter cohort validation studies are warranted to follow up the current single-site study.
Authors
- Dena Towner (ORCID: https://orcid.org/0000-0002-1767-4197)
- Alexandra Gurary (ORCID: https://orcid.org/0009-0007-3622-4734)
- Maarit Tiirikainen (ORCID: https://orcid.org/0000-0002-8124-3818)
- Cameron Lassiter (ORCID: https://orcid.org/0000-0003-2712-783X)
- Fadhl Alakwaa (ORCID: https://orcid.org/0000-0001-5349-7960)
- W. Steven Ward (ORCID: https://orcid.org/0000-0002-5025-192X)
- Ryan J. Schlueter (ORCID: https://orcid.org/0000-0003-0855-6874)
- Paula Benny (ORCID: https://orcid.org/0000-0001-9118-915X)
- Yuheng Du (ORCID: https://orcid.org/0000-0001-6665-5892)
- Annette Lum‐Jones
- Yuchen Shao (ORCID: https://orcid.org/0000-0001-7969-0734)
- Lana X. Garmire (ORCID: https://orcid.org/0000-0003-1672-6917)
Institutions
- University of Hawaiʻi at Mānoa (US)
- University of Hawaii System (US)
- University of Michigan (US)
- University of Hawaii Cancer Center
Publication Details
- Journal
- GigaScience
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gigascience/giaf039
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health
- National Cancer Institute
- U.S. National Library of Medicine
- Eunice Kennedy Shriver National Institute of Child Health and Human Development