DeTox: an <i>In-Silico</i> Alternative to Animal Testing for Predicting Developmental Toxicity Potential
DeTox can be employed to support regulatory assessment of pharmaceutical and cosmetic products aligned with the 3Rs of animal testing and to guide the development of safer drugs for pregnant populations. The curated dataset of developmental toxicants is publicly available, and all models are implemented in a public, user-friendly web tool, DeTox (<u>De</u>velopmental <u>Tox</u>icity), at https://detox.mml.unc.edu/. https://doi.org/10.1289/EHP15307.
Authors
- Kathleen M. Gates (ORCID: https://orcid.org/0000-0002-1246-4529)
- Marielle Rath (ORCID: https://orcid.org/0000-0001-9979-1727)
- Eugene Muratov (ORCID: https://orcid.org/0000-0003-4616-7036)
- James Wellnitz (ORCID: https://orcid.org/0000-0002-9181-3431)
- José Teófilo Moreira‐Filho (ORCID: https://orcid.org/0000-0002-0777-280X)
- Alexander Tropsha (ORCID: https://orcid.org/0000-0003-3802-8896)
- Holli‐Joi Martin (ORCID: https://orcid.org/0000-0002-9123-0439)
- Helena T. Högberg (ORCID: https://orcid.org/0000-0001-8034-6818)
- Nicole Kleinstreuer (ORCID: https://orcid.org/0000-0002-7914-3682)
- Ricardo Scheufen Tieghi
Institutions
- National Institute of Environmental Health Sciences (US)
- Predict (France) (FR)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1289/ehp15307
- Citations
- 3
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 3.60