New Cyclopeptide and γ-Butyrolactone Derivatives from an Endophytic Strain of <i>Cophinforma mamane</i>
From an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana, a previously undescribed γ-butyrolactone compound (<b>2</b>) and three new cyclopentapeptides (<b>3</b>-<b>5</b>) have been isolated from the same strain, along with the known (4<i>R)</i>-striatisporolide A (<b>1</b>). Their structures were elucidated through extensive spectral analysis and DP4+ calculations. The two γ-butyrolactone derivatives (<b>1</b>, <b>2</b>) exhibited moderate inhibitory activity against axenic Leishmania infantum amastigotes (IC<sub>50</sub> = 13.33 and 4.43 μM, respectively), while only compound <b>2</b> displayed cytotoxic activity on Jurkat cells (17% growth inhibition at 1 μg/mL) and weak antibacterial activity against Enterococcus faecalis (MIC = 64 μg/mL).
Authors
- Marieke Vansteelandt (ORCID: https://orcid.org/0009-0006-4268-8685)
- Mohamed Haddad (ORCID: https://orcid.org/0000-0001-5599-9980)
- Denis Jacquemin (ORCID: https://orcid.org/0000-0002-4217-0708)
- Sandra Bourgeade‐Delmas (ORCID: https://orcid.org/0000-0001-9027-765X)
- Jean‐Luc Stigliani (ORCID: https://orcid.org/0000-0002-9916-689X)
- Nicolás Fabre (ORCID: https://orcid.org/0000-0001-5896-5700)
- Jérôme Graton (ORCID: https://orcid.org/0000-0002-1114-200X)
- Carlos A. Amasifuén Guerra (ORCID: https://orcid.org/0000-0001-9752-8618)
- Elise Crossay
- Sergio Ortíz (ORCID: https://orcid.org/0000-0002-1596-4887)
- Fatima Barakat (ORCID: https://orcid.org/0009-0005-3764-8913)
- D. Titton
- Clara Litot
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Lebanese University (LB)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Institut Universitaire de France (FR)
- National University Toribio Rodríguez de Mendoza (PE)
- Laboratoire de Chimie de Coordination (FR)
- Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation (FR)
- Institut de Recherche pour le Développement (FR)
- Université de Strasbourg (FR)
- Nantes Université (FR)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1021/acsomega.5c01292
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut de Recherche pour le Développement
- Région Occitanie Pyrénées-Méditerranée